Centella Asiatica also known as Gotu Kola, Hydrocotyle, Asiatic Pennywort, Indian Pennywort and Tiger Grass
Centella Asiatica contains: asiatic acid, madecassic acid, madecassoside and asiaticoside.
✧ Asiatic acid stimulates wound healing by increasing collagen production and anti-inflammatory actions.
✧ Madecassic acid modulates epidermal inflammation reactions and reduce the activity of enzymes that contribute to the breakdown of the skin’s matrix or framework and restructures the extracellular matrix of the dermis, stimulates synthesis of collagen types I and III.
✧ Madecassoside has antioxidant properties. Madecassoside may also be an effective inhibitor of hyperpigmentation caused by UV irradiation. Madecassoside has several mechanisms including collagen synthesis and angiogenesis.
✧ Asiaticoside prevents ultraviolet photoaging, protects DNA from radiation exposure, hs wound healing effects, anti-inflammatory effects, and promotes liver protective activity.
The benefits of gotu kola provide strong anti-aging benefits due to its ability to intrinsically protect skin molecules from degradation. As a result, Centella Asiatica infused products may potentially work to prolong the skin’s youthful appearance. Topical application of Centella Asiatica products can also help bolster skin barrier function.
Centella Asiatica contains 6% asiatic acid, 28% madecassic acid, 13% asiaticoside and 53% madecassoside. The actual plant contains more madecassic acid and is geared more towards skin healing than skin tightening.
✧ Centella Asiatica may help protect the brain from damage due to toxic metal exposure
✧ Centella Asiatica extract was demonstrated to increase migration and adhesion of new skin cells to the wound site and increased the numbers of skin-producing cells.
✧ International Journal of Molecular Medicine found that Centella Asiatica may help protect against skin cancer caused by exposure to ultraviolet radiation.
✧ Researchers observed significant improvements in body weight and levels of stress hormones.
✧ More recently it has been shown to be a relevant therapeutic strategy for treating Alzheimer’s disease
I have researched quite a bit of ingredient, but this has got to be the one the most I’ve seen. It is an incredibly effective ingredient for skin care and other health-related issues.
According to 40+ peer-reviewed research papers, Centella Asiatica / Gotu Kola:
✧ Boosts the production of fibronectin, collagen type I, collagen type III, and stimulates fibroblast proliferation, for tighter, firmer skin and connective tissue
✧ Protects elastin and hyaluronic acid from breakdown, thereby protecting skin elasticity, health, and hydration
✧ Fights skin aging and wrinkles, due to this combined actions on collagen, elastin and hyaluronic acid
✧ Improves stretch marks and cellulite
✧ Prevents hypertrophic scars and keloids
✧ Treats burns
✧ Accelerates wound healing
✧ Prevents and treats fibrosis
✧ Repairs skin and blood vessels
✧ itching, pain, puffiness, restlessness, cramps, and tiredness
✧ Protects from sun damage
✧ Treats hyperpigmentation
✧ Reduces skin dryness
✧ Has anti-inflammatory properties
✧ Is a powerful antioxidant
✧ Fights glycation
✧ Increases Serotonin and Dopamine and Lowers Cortisol (high-stress levels increase your body’s production of the hormone cortisol, which increases appetite and leads to weight gain.)
✧ Prevents vitiligo by protecting melanin cells from oxidative damage
✧ Improves the skin’s protective barrier function, thereby also boosting skin hydration
✧ Treats fat tissue inflammation
✧ Stimulates lipolysis better than caffeine
✧ Boosts lower leg tissue oxygenation, removal of carbon dioxide from tissues and reduces ankle swelling/edema, leg heaviness,
✧ Improves chronic venous insufficiency (CVI), lymphoedema, vein hypertension, varicose veins, hemorrhoids and phlebitis
✧ Diabetics avoid the clinical stages of vein disease
✧ Stabilises arterial plaque and prevent atherosclerosis
✧ Protects veins from the aftermath of deep vein thrombosis (DVT)
✧ Protects blood vessel walls and repairs leaky capillaries, thereby improving water retention
Historically, gotu kola has also been used to treat syphilis, hepatitis, stomach ulcers, mental fatigue, epilepsy, diarrhea, fever, and asthma. Today, in the U.S. and Europe gotu kola is most often used to treat varicose veins and chronic venous insufficiency, a condition where blood pools in the legs. It’s also used in ointments to treat psoriasis and help heal minor wounds.
Centella Asiatica is an ingredient in Acti-Labs products: Lipo Sculpting Fluid; Micellar Lotion; Air Brush Smoothing Serum.
✿ Centella and its Cosmetic applications
✿ Madecassoside isolated from Centella asiatica herbs facilitates burn wound healing in mice.
✿ Madecassoside Inhibits Melanin Synthesis by Blocking Ultraviolet-Induced Inflammation
✿ Triterpene Composition and Bioactivities of Centella asiatica
✿ Asiatic Acid Alleviates Hemodynamic and Metabolic Alterations via Restoring eNOS/iNOS Expression, Oxidative Stress, and Inflammation in Diet-Induced Metabolic Syndrome Rats
✿ PDF: In vitro and in vivo wound healing activity of asiaticoside isolated from Centella asiatica
✿ Neurological Sciences: Mitoprotective Effect of Centella Asiatica Against Aluminum-Induced Neurotoxicity in Rats: Possible Relevance to Its Anti-Oxidant and Anti-Apoptosis Mechanism
✿ Phytomedicine: Asiaticoside Enhances Normal Human Skin Cell Migration, Attachment and Growth in Vitro Wound Healing Model
✿ International Journal of Molecular Medicine: Centella Asiatica Protects Against UVB-Induced Hacat Keratinocyte Damage Through Microrna Expression Changes
✿ Clinical, biometric and structural evaluation of the long-term effects of a topical treatment with ascorbic acid and madecassoside in photoaged human skin
✿ Comparative activity of asiaticoside and madecassoside on type I and III collagen synthesis by cultured human
✿ Evaluation of the effects of a preparation containing asiaticoside on periocular wrinkles of human volunteers
✿ Effect of Centella asiatica L (Umbelliferae) on normal and dexamethasone-suppressed wound healing in Wistar Albino rats
✿ PDF: Centella asiatica in Dermatology: An Overview
✿ PDF: GOTU KOLA EXTRACT PROTECTS SKIN CELLS FROM UV-B RADIATION
✿ Skin Ageing: Natural Weapons and Strategies
✿ PDF: Gotu Kola Exposure Protects Adult Skin Fibroblasts from Oxidative Stress
✿ PDF: Triterpene Composition and Bioactivities of Centella asiatica
✿ In vitro keratinocyte antiproliferant effect of Centella asiatica extract and triterpenoid saponins
✿ Asiaticoside induces human collagen I synthesis through TGFbeta receptor I kinase (TbetaRI kinase)-independent Smad signaling
✿ Titrated extract of Centella asiatica increases hair inductive property through inhibition of STAT signaling pathway in three-dimensional spheroid cultured human dermal papilla cells
✿ Dermal fibroblast-associated gene induction by asiaticoside shown in vitro by DNA microarray analysis
✿ Anti-Inflammatory Effect of Titrated Extract of Centella asiatica in Phthalic Anhydride-Induced Allergic Dermatitis Animal Model
✿ Centella asiatica extracts modulate hydrogen peroxide-induced senescence in human dermal fibroblasts
✿ Protective effect of madecassoside on H2O2-induced oxidative stress and autophagy activation in human melanocytes
✿ Titrated extract of Centella asiatica provides a UVB protective effect by altering microRNA expression profiles in human dermal fibroblasts
✿ Moisturizing and Antiinflammatory Properties of Cosmetic Formulations Containing Centella asiatica Extract
✿ Development of a High-Performance Liquid Chromatographic Method for Asiaticoside Quantification in Different Skin Layers after Topical Application of a Centella asiatica Extract
✿ Effects of Centella asiatica extract on mucopolysaccharide metabolism in subjects with varicose veins
✿ Chemical, pharmacological and clinical profile of the East Asian medical plant Centella asiatica
✿ Madecassoside inhibits melanin synthesis by blocking ultraviolet-induced inflammation
✿ Anti-inflammaging and antiglycation activity of a novel botanical ingredient from African biodiversity (centevita)
✿ Centella asiatica in cosmetology
✿ PDF: Moisturizing and Antiinflammatory Properties of Cosmetic Formulations Containing Centella asiatica Extract
✿ Matrix metalloproteinase, hyaluronidase and elastase inhibitory potential of standardized extract of Centella asiatica
✿ PDF: Matrix Metalloproteinase, Hyaluronidase and Elastase Inhibitory Potential of Standardized extract of Centella asiatica (L.) Urban.
✿ Asiaticoside induces human collagen I synthesis through TGF-beta receptor I kinase (TbetaRI kinase)-independent Smad signaling
✿ PDF: Safety Assessment of Centella asiatica-derived Ingredients as Used in Cosmetics
✿ Effects of total triterpenes of Centella asiatica on the corticosterone levels in serum and contents of monoamine in depression rat brain
✿ Journal of Ethnopharmacology: Anxiolytic Effects of Standardized Extract of Centella Asiatica (Eca 233) After Chronic Immobilization Stress in Mice
✿ 1,101 Research Data on the effects of Centella Asiatica published in the US National Library of Medicine National Institutes of Health